Coevolutionary training of phages can be more successful in several small, relative to single large, habitats.

Authors

Xiao Liu, Quan-Guo Zhang

Published in

mLife. Volume 4. Issue 2. Pages 223-225. Epub Mar 12, 2025.

Abstract

Evolutionary training of phages can help to counter bacterial resistance evolution. Here, we address whether metapopulation processes can enhance the evolution of phage infectivity. Our experiment with a model bacterium-phage system supported a prediction of long-term fluctuating selection dynamics. Specifically, metapopulations of several small habitats showed greater total infectivity ranges by supporting more diverse phages, compared with single large populations. Crucially, the advantage of several small habitats was conditioned on blocking bacterial dispersal within metapopulations. We conclude that well-designed metapopulation training programs can be useful for quick and easy preparation of cocktail phage materials.

PMID:
40313981
Bibliographic data and abstract were imported from PubMed on 02 May 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.