The legacy of William M. Pardridge (1947-2024) on the science and fields concerned with the physiology of the blood-brain barrier and the transport of drugs to the brain.

Authors

Ruben J Boado, Ulrich Bickel, Rachita K Sumbria

Published in

Fluids and barriers of the CNS. Volume 22. Issue 1. Pages 46. May 07, 2025. Epub May 07, 2025.

Abstract

This article highlights the scientific achievements and professional career of William M. Pardridge, who passed away on 18th of June 2024. He was born in 1947 in Bethesda, Maryland, USA. William, known affectionately as Bill, was one of the most influential researchers in the blood-brain barrier (BBB) field. Bill's research contributions to the field spun over 6 decades at the University of California, Los Angeles, and it was focused on the molecular physiology of the BBB, including the carrier-mediated transport of nutrients and small molecule drugs, the receptor-mediated transport of peptides and molecular Trojan horses, gene therapy of the brain with Trojan horse liposomes, and BBB genomics and proteomics. He founded ArmaGen Inc. in 2004, a biotech company that provided the basis for the treatment of CNS disorders with the molecular Trojan horse technology. This technology continues to be widely used in academia and in the biotech industry. He has been a cherished friend and mentor to many within the BBB community.

PMID:
40335998
Bibliographic data and abstract were imported from PubMed on 08 May 2025.

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