Chromatographic Detection and Determination of Cyproheptadine and Dexamethasone as Adulterants in Weight Gain Supplements.

Authors

Arwa Ilyas Ahmed, Hasan Saad Aldewachi, Mohammed Ibrahim Aladul

Published in

Journal of AOAC International. May 08, 2025. Epub May 08, 2025.

Abstract

The increasing popularity of herbal medicines and dietary supplements has raised concern about potential adulteration with pharmaceutical drugs.
To detect and determine cyproheptadine (CYP) and dexamethasone (DEX) as adulterants in weight gain herbal supplements found in the Iraqi market.
Nine herbal supplements marketed as natural weight gainers were purchased from local pharmacies and were screened using high-performance liquid chromatography (HPLC) for qualitative and quantitative detection of CYP and DEX.
CYP was detected in seven of the nine products at levels of 2.65-8.6 mg per dosage unit. DEX was detected in all test solutions at levels of 6.2-18.75 mg per dosage unit.
A large proportion of herbal weight gain supplements were found to contain undeclared pharmaceuticals with severe health implications. The findings call for the immediate institution of tighter regulatory control and regular quality control tests in the name of consumer safety.
Herbals and supplements for weight gain are increasingly popular but may be adulterated with pharmaceutical drugs which impose serious health risks for consumers. Urgent need for regulatory enforcement and routine quality checks are recommended.

PMID:
40341529
Bibliographic data and abstract were imported from PubMed on 09 May 2025.

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