Role of Intestinal Microbiome in Potentiating Inflammation and Predicting Outcomes in Alcohol-Associated Cirrhosis.

Authors

Sidsel Støy, Bernd Schnabl

Published in

Gastroenterology clinics of North America. Volume 54. Issue 2. Pages 453-467. Epub Jan 18, 2025.

Abstract

In patients with alcohol-associated cirrhosis, the intestinal microbiome composition is disturbed with a loss of beneficial functions and an increase in pathobionts. These changes are associated with disease severity and decompensation, due in part to the exacerbation of liver inflammation by an altered microbiome. Microbes or their antigens may translocate to the liver to potentiate the activation of immune cells and thereby contribute to inflammatory injury. Moreover, microbes may aggravate liver disease through the production of toxins or metabolites, via the effects on bile acids or the intestinal immune system.

PMID:
40348498
Bibliographic data and abstract were imported from PubMed on 12 May 2025.

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