Enantiomeric diarylheptanoids from Ottelia acuminata var. acuminata and their α-glucosidase inhibitory activity.

Authors

Jia-Ru Zhou, Xin-Yue Hu, Hong-Xing Liu, Yu Zhou, Fei-Fei Xiong, Jian-Jun Zhao, Xing-Ren Li, Gang Xu

Published in

Natural products and bioprospecting. Volume 15. Issue 1. Pages 33. May 16, 2025. Epub May 16, 2025.

Abstract

Otteacumienes G-K (1-5), five pairs of enantiomeric diarylheptanoids, along with one undescribed diarylheptanoid glycoside and one new lignan, were isolated from Ottelia acuminata var. acuminata. Compounds 1-5 were identified as five pairs of enantiomers and their structural configurations were determined through a combination of spectroscopic analysis, X-ray crystallography, and ECD calculation. Notably, compound 6 was the first diarylheptanoid glycoside isolated from this aquatic species, and its absolute configuration was unequivocally established through semi-synthesis. Biological evaluation demonstrated that compound 1 exhibited α-glucosidase inhibitory activity, with an inhibition ratio of 38.97% (acarbose as the positive control, inhibition ratio = 13.52%).

PMID:
40377804
Bibliographic data and abstract were imported from PubMed on 16 May 2025.

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