Authors
Badriah Saad Al-Farhan, Ahmed Abdulhafez Hamad
Published in
Journal of fluorescence. May 16, 2025. Epub May 16, 2025.
Abstract
Recently, a new antipsychotic treatment called brexpiprazole (BPZ) has been used to treat schizophrenia and other forms of psychosis. A straightforward, sensitive, precise, and environmentally friendly spectrofluorimetric technique was developed to measure it by forming an ion-pair association complex with Eosin Y. The dye's intrinsic fluorescence recorded at λem = 540 nm (λex was 302 nm), is reduced when an ion-pair complex develops. The approach's settings for generating the brexpiprazole-eosin dye association complex were adjusted in the concepts of analysis. In the Britton-Robinson neutralizing solution (pH 4.0), the reaction was conducted. In the 100-1500 ng mL- 1 range, the dye's fluorescence emission intensity dropped linearly, and the correlation value was 0.9998. The values for the sensitivity (LOQ & LOD) limits were 83.4 and 27.5 ng mL- 1. The ICH standards have been followed in the validation of the suggested approach. Moreover, content uniformity analysis was also successfully conducted with it. Finally, the established system's greenness was evaluated using several recent analytical tools: the Eco-Scale, the Analytical Greenness metric approach (AGREE), the National Environmental Method Index (NEMI), the Green Analytical Procedure Index (GAPI), and GSST (Green Solvents Selecting Tool). Also, the method's whiteness, as well as blueness, were evaluated using modern Red Green Blue 12 model (RGB12) and Blue Applicability Grade Index (BAGI) tools.
PMID:
40377797
Bibliographic data and abstract were imported from PubMed on 16 May 2025.
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