Combining ranibizumab with calcium dobesilate to reduce injection frequency in diabetic macular edema treatment.

Authors

Jian-Ying Chen, Hong-Wei Pan, Xiao-Ming Zhang, Jing-Min Liu, Sum-Yuet Chan, Ting-Ting Liu, Jian-Yi Ma, Qi Liu, Wan-Zhao Yi, Ya-Ni Wu, Shuo-Shuo Gu, Ling-Xiao Xia, Jing Meng

Published in

International ophthalmology. Volume 45. Issue 1. Pages 203. May 17, 2025. Epub May 17, 2025.

Abstract

This study explores the potential of calcium dobesilate combined with intravitreal ranibizumab injections to reduce the treatment frequency in patients with DME-induced visual impairment and observes the clinical outcomes.
In this investigation involving 90 DME patients, a comparative analysis was conducted between a group treated with both ranibizumab injections and calcium dobesilate capsules (45 patients) and a control group receiving only the injections (45 patients). Treatment was monthly for 3 months, then adjusted as needed, with a follow-up at 12 months focusing on injection frequency, BCVA scores, and CMT to assess both treatment efficacy and safety.
In the 12-month trial, subjects receiving a new combination therapy experienced fewer required intravitreal injections (average 4.73) compared to those on standard monotherapy (average 6.02), showing a significant reduction (p < 0.05). Final assessments revealed substantial improvements in best corrected visual acuity (BCVA) and central macular thickness (CMT) for both groups from baseline (p < 0.05). The experimental group notably showed greater enhancements in BCVA and CMT, highlighting the superior effectiveness of the combination therapy in managing DME symptoms with reduced treatment frequency.
Combination therapy with calcium dobesilate and ranibizumab decreased the frequency of intravitreal injections and led to greater improvements in BCVA and CMT compared to ranibizumab alone over 12 months. Both treatments were well-tolerated, with the combination therapy demonstrating a favorable safety profile.

PMID:
40381058
Bibliographic data and abstract were imported from PubMed on 18 May 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.