Selective Alkylarylation Difunctionalization of 1,3-Butadienes via Nickel/Photoredox Dual Catalysis.

Authors

Aidana Gimnkhan, Rajesh Kancherla, Krishnamoorthy Muralirajan, Magnus Rueping

Published in

Organic letters. May 19, 2025. Epub May 19, 2025.

Abstract

Photocatalytic multicomponent reactions are at the forefront of organic synthesis. In recent years, the dicarbofunctionalization of olefins has received significant attention, with nickel serving as a key transition metal catalyst under photochemical conditions. However, achieving regioselective 1,4-alkylarylation of dienes with alkyl and aryl bromides remains challenging. In this work, we present a Ni/photoredox dual catalysis approach for the regioselective alkylarylation of dienes, offering a mild reaction that eliminates the need for stochiometric metal reductants. Broad substrate scope and mechanistic investigations are presented that support the proposed reaction mechanism.

PMID:
40388654
Bibliographic data and abstract were imported from PubMed on 20 May 2025.

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