Authors
Mikkel T Olsen, Maria Panagiotou, Knut J Strømmen, Carina K Klarskov, Peter L Kristensen, Stavroula Mougiakakou
Published in
Diabetes technology & therapeutics. May 21, 2025. Epub May 21, 2025.
Abstract
Objective: All continuous glucose monitors (CGMs) have an upper detection limit, typically of 22.2 mmol/L. This might bias CGM metrics. We aimed to develop and validate a statistical model for imputing values above this limit. Methods: We analyzed CGM data from 85 inpatients with type 2 diabetes, 705 outpatients with type 1 diabetes, and 27 outpatients with type 2 diabetes. A Bayesian nonparametric latent Gaussian process regression model was applied to the CGM data intentionally right censored for the top 5%, 10%, 20%, and 30% and compared with the uncensored CGM data by the bias, mean squared error (MSE), and coefficient of determination (R2) of mean glucose, standard deviation (SD), and coefficient of variation (CV). Results: In hospitalized patients with diabetes, outpatients with type 1 diabetes, and outpatients with type 2 diabetes for 5% to 30% right censoring, respectively, the bias on mean glucose after imputation ranged from -0.012 to 0.362, -0.018 to 0.485, and -0.008 to 0.130, respectively. Bias on SD ranged from -0.024 to 0.226, -0.033 to 0.381, and -0.016 to 0.138, respectively. Bias on CV ranged from -0.207 to 1.543, -0.316 to 2.609, and -0.222 to 1.721, respectively. Similar results indicating good performance of the imputation model were observed for MSE and R2. Conclusions: An imputation model for glucose values above the upper detection limit of CGMs was developed and validated in various populations. This enables a more unbiased quantification of CGM metrics for patients with severe hyperglycemia.
PMID:
40397649
Bibliographic data and abstract were imported from PubMed on 22 May 2025.
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