Transition-Metal-Free, Intramolecular Oxidative Coupling of C(sp³)-B with C(sp²)-H.

Authors

Tingting Dan, Yuling Liu, Lai Li, Wenwen Yang, Mingyu Yang, Zhangjie Shi

Published in

Organic letters. May 28, 2025. Epub May 28, 2025.

Abstract

Alkylboron reagents have historically posed significant challenges in transition-metal catalysis, primarily due to the comparable electronegativities of carbon (C) and boron (B), which results in weakly polarized C-B bonds that hinder efficient transmetalation. Additionally, the propensity for β-hydride elimination further complicates the transmetalation process, limiting their applicability in synthetic transformations. In this study, we present a groundbreaking transition-metal-free strategy for the intramolecular coupling of C(sp³)-B with C(sp²)-H bonds. This innovative approach operates under mild reaction conditions, exhibits exceptional functional group compatibility, and enables the efficient construction of diverse polycyclic carbon frameworks.

PMID:
40435340
Bibliographic data and abstract were imported from PubMed on 29 May 2025.

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