Lewis acid-catalyzed intramolecular cyclization of 7-alkynylcycloheptatrienes with carbonyls: access to 3,4-disubstituted 2,5-dihydropyrroles.

Authors

Xiang Huang, Jin-Ming Yang

Published in

Chemical communications (Cambridge, England). Jun 04, 2025. Epub Jun 04, 2025.

Abstract

We herein report a Lewis acid-catalyzed intramolecular cyclization of 7-alkynylcycloheptatrienes with carbonyls. A variety of highly functionalized 2,5-dihydropyrroles were obtained in moderate yields. This protocol straightforwardly led to a solvent-controlled divergent synthesis of 2,5-dihydropyrroles, which may serve as privileged skeletons in drug discovery. Additionally, scale-up reactions and late-stage derivatizations highlight the potential synthetic utility of this methodology.

PMID:
40465565
Bibliographic data and abstract were imported from PubMed on 05 Jun 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.