Authors
Menghui Chi, Leyuan Zhang, Bing Deng, Jing Lin, Qian Wang, Lina Zhang, Min Yin, Lingwen Gu, Daohao Li, Guiqiu Zhao, Cui Li
Published in
Journal of materials science. Materials in medicine. Volume 36. Issue 1. Pages 48. Jun 06, 2025. Epub Jun 06, 2025.
Abstract
The blindness rate of fungal keratitis is high, however, traditional therapy, like eye drops, has poor bioavailability. To make the traditional treatment more effective, new drug-loading system was explored, which can attach to the ocular surface to prolong the release time of natamycin (NATA). Sodium alginate (SA) has attractive properties of biocompatibility, biodegradability, which have been exploited to be natural-origin polymer of drug release. Because of special egg box structure of SA, the sodium ions in the structure can be exchanged with divalent cations through crosslinking, which could control the pore size inside the material and release rate of the loaded drug. Here, we utilized the composite of sodium alginate and polyethylene oxide (PEO) with natamycin loaded through crosslinking with calcium ion ethanol aqueous solution to delay drug release and treat fungal keratitis. The results from experiments proved that the membrane with the slowest rate of drug release was the group with the ratio of ethanol to water 2:1, and the 1% natamycin-loaded films could effectively inhibit the growth of Aspergillus fumigatus. SA-PEO membranes could reduce the inflammatory response. Conclusively, NATA-SA-PEO films could be considered a useful approach to prolong ocular natamycin maintenance and improve the outcome of fungal keratitis.
PMID:
40478454
Bibliographic data and abstract were imported from PubMed on 06 Jun 2025.
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