Perioperative Severe Complications Can Cause Pancreatic Graft Failure and Mortality in Pancreas Transplantation.

Authors

Takahisa Hiramitsu, Tomoki Himeno, Yuki Shimamoto, Yuki Hasegawa, Kenta Futamura, Manabu Okada, Toshihiro Ichimori, Yoshihiko Watarai, Shunji Narumi

Published in

Transplantation proceedings. Jun 14, 2025. Epub Jun 14, 2025.

Abstract

Pancreas transplantation (PTx) is a radical treatment for type 1 diabetes, frequently associated with complications. Herein, we examined the impact of severe perioperative complications on pancreatic graft and recipient survival.
Between January 2010 and December 2024, 40 patients with type 1 diabetes underwent PTx: 35 underwent simultaneous PTx and kidney transplantation, and 5 underwent PTx after kidney transplantation. Pancreatic graft and recipient survival rates were compared between recipients with and without severe perioperative complications defined by grades more severe than grade Ⅱ in the Clavien-Dindo classification, using the Kaplan-Meier survival curve and log-rank tests.
Although severe perioperative complications were identified in 12 recipients (30.0%), no perioperative mortality was observed. Pancreatic graft failure and mortality occurred in 4 (33.3%) and 3 (25.0%) recipients, respectively, along with severe perioperative complications. In contrast, in recipients without severe perioperative complications, pancreatic graft failure and mortality occurred in 3 (10.7%) and 1 (3.6%) recipients, respectively. Pancreatic graft failure and recipient mortality were significantly higher in recipients with severe perioperative complications than in those without severe perioperative complications (P = .024 and P = .017, respectively).
Severe perioperative complications can result in pancreatic graft failure and mortality. Appropriate surgical interventions are required to prevent severe perioperative complications.

PMID:
40517104
Bibliographic data and abstract were imported from PubMed on 15 Jun 2025.

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