Authors
Huang-Jie Li, Shunxing Li, Ya-Lin Zhang, Fengjiao Liu, Zhao-Jing Huang, Jia-Yi Luo, Fengying Zheng, Li-Guo Yang, Ke Shi, Feng-Juan Han
Published in
Analytical chemistry. Jun 18, 2025. Epub Jun 18, 2025.
Abstract
Coordination polymers (CPs) have gained significant attention due to their unique structural tunability and broad application prospects. However, their instability in water remains a key challenge for practical applications. This study presents a dual-channel fluorescent sensor based on water-unstable zinc coordination polymers (Zn-CPs) for the sensitive detection of copper ions (Cu2+) in water and cysteine (Cys) in serum. Zn-CPs underwent structural collapse in water, deactivating matrix coordination-induced emission (MCIE) and quenching blue fluorescence. pH adjustment activated the aggregation-induced emission (AIE) of the ligand, turning on green fluorescence. The introduction of Cu2+ facilitated the formation of zinc-copper co-coordination polymers (Zn/Cu-CPs), improving water stability while preserving blue fluorescence and inhibiting green fluorescence activation. In contrast, Cys competitively coordinated with Cu2+, preventing the formation of Zn/Cu-CPs, resulting in blue fluorescence quenching and green fluorescence activation. The sensor exhibited a linear detection range of 0.01-0.25 mg/L for Cu2+ (limit of detection: 0.0162 mg/L) and 0.5-14 μM for Cys (limit of detection: 0.4380 μM). Unlike conventional approaches that focus on enhancing water stability, this study highlights the potential of water-unstable coordination polymers in environmental and bioanalytical applications and provides new insights into the design of fluorescence sensors based on structural transformations.
PMID:
40532065
Bibliographic data and abstract were imported from PubMed on 19 Jun 2025.
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