Complete genome sequence of a tetracycline-resistant Streptococcus mutans strain carrying the tet(M) gene.

Authors

Saki Nishihama, Yujin Suzuki, Tomoaki Shintani, Manami Tsunoi, Junzo Hisatsune, Yo Sugawara, Katsuhiro Takeda, Miki Kawada-Matsuo, Mikihito Kajiya, Motoyuki Sugai, Hideki Shiba, Hitoshi Komatsuzawa

Published in

Journal of oral biosciences. Pages 100679. Jun 20, 2025. Epub Jun 20, 2025.

Abstract

Tetracyclines are widely used in dental treatment. Here, we report the genomic information of the tetracycline-resistant Streptococcus mutans strain, HSM45, for the first time.
Susceptibility to tetracycline was determined using the microdilution method. The complete genome sequence of HSM45 was determined and compared with public genome data.
HSM45 was resistant to tetracycline. The tetracycline resistance gene tet(M) was carried by Tn916, a conjugative transposon that is widely found in Gram-positive bacteria.
This study showed that S. mutans can acquire tetracycline resistance and it can also be a source of horizontal transfer of resistance genes.

PMID:
40545135
Bibliographic data and abstract were imported from PubMed on 23 Jun 2025.

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