Postoperative Complications After Cytoreductive Surgery for Advanced Ovarian Carcinoma: A Single-Center Analysis Exploring the Value of the Comprehensive Complication Index and the Predictors of High Complications Burden.

Authors

Tommaso Bianchi, Tommaso Grassi, Elena De Ponti, Giorgia Pecis Cavagna, Martina Bombelli, Daniele Lugotti, Filippo Testa, Mauro Totis, Gaetano Trezzi, Fabio Landoni, Robert Fruscio

Published in

Annals of surgical oncology. Jun 24, 2025. Epub Jun 24, 2025.

Abstract

The comprehensive complication index (CCI) reflects the overall patient complication burden on a 0-100 scale. This single-institution retrospective analysis explores the accuracy of CCI in describing complications following cytoreductive surgery for advanced high-grade ovarian carcinoma (HGOC) and aims to identify predictive factors of high complication burden.
In total, 304 patients who underwent cytoreductive surgery for FIGO stage IIIA-IVB HGOC at our institution from 2015 to 2023 were analyzed. Each complication's severity was graded using the Clavien-Dindo classification. The CCI was used to quantify the global complications burden, and patients were stratified into three groups: CCI-low (< 26.2), CCI-intermediate (26 ≤ CCI < 33.7), and CCI-high (≥ 33.7).
Of the 200 patients (65.8%) with at least one complication, 127 (41.8%) were CCI-low, 32 (10.5%) CCI-intermediate, and 41 (13.5%) CCI-high. Median hospitalization duration (p < 0.0001) and readmission rates (p < 0.0001) correlated with CCI categories, reflecting increased CCI scores with greater surgical complexity, as assessed by the Aletti surgical complexity score (SCS). Univariate analysis showed a significant association between CCI-high and FIGO stage, surgical complexity, diaphragmatic procedures, multiple bowel resections, length of surgery and intraoperative blood loss. Multivariate analysis confirmed FIGO stage (odds ratio [OR] 2.57), multiple bowel resections (OR 5.61), and blood loss (OR 1.93) as independent risk factors for high complication burden.
The CCI is a good descriptor of postoperative complications in patients undergoing cytoreductive surgery for advanced HGOC by integrating both the severity and number of complications into a single, easily usable, and intuitive quantitative score. FIGO stage, multiple bowel resections, and blood loss-but not surgical timing-are independent predictors of a high complication burden.

PMID:
40553357
Bibliographic data and abstract were imported from PubMed on 24 Jun 2025.

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