Visible Light-Mediated Spiroannulation of o-Alkynyl Acrylamides Using Excited-State Palladium Catalysis.

Authors

Kirti Khanna, Ganesh Chandra Upreti, Parashuram Sharma, Shreya Sharma, Anand Singh

Published in

The Journal of organic chemistry. Jun 25, 2025. Epub Jun 25, 2025.

Abstract

A photoinduced, Pd-catalyzed spiroannulation of 1,7-enynes has been developed. This reaction employs simple alkyl halides as radical precursors to initiate a radical addition/cyclization cascade of o-alkynyl acrylamides, resulting in spiroannulated tetracyclic systems. Using a widely available and simple palladium catalyst, this protocol demonstrates good scope and functional group tolerance under mild reaction conditions and provides expedient access to complex spirocyclic molecular architectures.

PMID:
40557466
Bibliographic data and abstract were imported from PubMed on 25 Jun 2025.

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