Rhodium-catalyzed enantioselective transfer hydrogenation of α-chloro β-ketophosphonates via dynamic kinetic resolution.

Authors

Jun Wang, Xiaobing Ding, Sai Ruan, Longsheng Zheng, Virginie Ratovelomanana-Vidal, Gen-Qiang Chen, Xumu Zhang

Published in

Chemical communications (Cambridge, England). Jun 27, 2025. Epub Jun 27, 2025.

Abstract

A rhodium-catalyzed asymmetric transfer hydrogenation (ATH) of α-chloro β-ketophosphonates via dynamic kinetic resolution (DKR) has been developed. A wide range of syn α-chloro β-hydroxyphosphonates were efficiently synthesized with high yields and excellent enantio- and diastereoselectivities (up to 99% ee and > 99 : 1 dr) under mild reaction conditions. A gram-scale experiment was conducted successfully, which offers a straightforward approach to a key intermediate of fosfomycin.

PMID:
40575869
Bibliographic data and abstract were imported from PubMed on 27 Jun 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.