Authors
Alexandr Gish, Alexandre Peyré, Camille Richeval, Eric Pleignet, Victoire Cottereau, Jean-Michel Gaulier, Damien Alain Devault
Published in
Environmental science and pollution research international. Jun 27, 2025. Epub Jun 27, 2025.
Abstract
At a time when synthetic drugs are emerging as a critical threat to users, the consumption of synthetic cannabinoid receptor agonists has become emblematic of the French overseas territory of Mayotte, aka "la Chimique." On this island, 8 sampling campaigns of this drug were performed between September 22 and September 23: 193 samples were collected. Among them, 21 contained ADB-FUBIATA. This synthetic cannabinoid receptor agonist presented maximal concentrations. To verify the feasibility of further epidemiological studies based on wastewater and with a view to forensic and ecotoxicological concerns since metabolites are known to be capable of altering the environment, the authors studied the hepatic metabolism of ADB-FUBIATA using HLMs and LC-HMRS. For tracking ADB-FUBIATA, the apparently most relevant metabolite is proposed, i.e., the M03 metabolite (C23H26FN3O3, HMRS target must be [M+H+] m/z 412.2031) resulting from ADB-FUBIATA hepatic hydroxylation, but persistent in the wastewater context. This proposal remains cautious, since it is based on a metabolization rate of 10% estimated on the basis of the intensity of the chromatographic peak area. Nevertheless, to confirm the usefulness and viability of detecting ADB-FUBIATA metabolites in wastewater, it is necessary to carry out analytical confirmation on real samples.
PMID:
40576895
Bibliographic data and abstract were imported from PubMed on 27 Jun 2025.
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