Bioorthogonal Chemistry of Water-Soluble Blue Fluorescent Coumarin-Substituted Azole Derivatives for Bioimaging and Bioconjugation Applications.

Authors

Ilavarasan Vickraman, Zhoveta Yhobu, Jan Grzegorz Małecki, Kavina Ganapathy, Ahipa Tantri Nagaraja, Srinivasa Budagumpi

Published in

ACS applied bio materials. Jul 09, 2025. Epub Jul 09, 2025.

Abstract

Blue fluorescent azolium salts with higher Stokes shift, increased water solubility, and bioorthogonal functionality were synthesized and explored. The promising molecules among the synthesized compounds exhibited a quantum yield of approximately 0.40 in biologically relevant buffer solutions. These derivatives were further examined for bioimaging and bioorthogonality under aqueous conditions.

PMID:
40633051
Bibliographic data and abstract were imported from PubMed on 10 Jul 2025.

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