FAPI-Negative but FDG-Avid Hepatocellular Carcinoma With Extensive Steatosis.

Authors

Yuhu Lv, Mengting Li, Xiaoli Lan, Chunxia Qin

Published in

Clinical nuclear medicine. Jul 08, 2025. Epub Jul 08, 2025.

Abstract

An 80-year-old man underwent 68Ga-FAPI and 18F-FDG PET scans to determine the nature of a liver mass that exhibited high FDG uptake unexpectedly but was FAPI-negative. Postoperative pathology confirmed atypical hepatocellular carcinoma (HCC) with extensive steatosis. Intratumoral steatosis is uncommon in large lesions, and extensive steatosis may mask tumor characteristics, which increases diagnostic complexity. This unusual case provides novel insights into the clinical application of FDG and FAPI PET and highlights the importance of recognizing FAPI false-negatives, thereby contributing to clinical practice.

PMID:
40644592
Bibliographic data and abstract were imported from PubMed on 12 Jul 2025.

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