TSJT1 and glutamate is required for aluminum tolerance associated with mitochondrial pyruvate carrier 1 in Arabidopsis.

Authors

Chao Yuan, Lilong He, Donghua Chen, Jianwei Gao, Wei Zhang

Published in

Plant signaling & behavior. Volume 20. Issue 1. Pages 2526765. Epub Jul 14, 2025.

Abstract

Aluminum stress is a critical limiting factor in crop productivity, as it rapidly inhibits root elongation, impairs water and nutrient uptake, and ultimately leads to substantial yield reductions. To address this challenge, it is essential to elucidate the mechanisms underlying plant aluminum toxicity and tolerance, thereby enhancing crop resilience to aluminum stress. In this study, we employed transcriptomic and metabolomic analyses to identify the protein TSJT1, which is induced by aluminum exposure and plays an essential role in the plant's response to aluminum. Notably, TSJT1 expression was significantly up-regulated in mpc1 mutants; furthermore, overexpression of TSJT1 markedly enhanced the plant's resistance to aluminum stress. Our integrated analysis also revealed significant differences in glutamate metabolites as well as a protein encoding glutamate synthetase during this process. Through exogenous glutamate supplementation, we demonstrated that glutamate plays a critical role in the MPC1-mediated response to aluminum stress.

PMID:
40654021
Bibliographic data and abstract were imported from PubMed on 14 Jul 2025.

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