Hippocampal Oligodendrocytes Regulate Mossy Fiber Development Involved in Epileptic Responses.

Authors

Chunxia Jiang, Yunan Hu, Feng Zhang, Mengsheng Qiu, Xiaofeng Zhao

Published in

Neuroscience bulletin. Jul 17, 2025. Epub Jul 17, 2025.

Abstract

Although oligodendrocytes (OLs) are known to form the myelin sheath around neuronal axons for the saltatory conduction of action potentials, recent studies have suggested that OLs also modulate neuronal function and plasticity. In the present study, we found that OL maturation deficiency in Myrf-CKO mice caused spontaneous epileptogenesis and resulted in death. To further investigate the association between OL development and epilepsy, we examined the Adamts4 KO mouse line, which has a mild OL differentiation phenotype in the hippocampus. As a result, the differentiation defect in the mutant hippocampus reduced the expression of myelin-associated glycoprotein and lessened its inhibition of the dephosphorylation of phosphorylated tropomyosin-related kinase B, which is associated with retarded adolescent hippocampal mossy fiber development and higher susceptibility to epileptogenesis in adulthood. More importantly, enhancing differentiation by orally administered clemastine rescues the defective mossy fiber development in the early postnatal period and attenuates epilepsy susceptibility in adults. Together, these results strongly suggest that an OL differentiation defect in the hippocampus may contribute to susceptibility to epilepsy in adults.

PMID:
40673958
Bibliographic data and abstract were imported from PubMed on 17 Jul 2025.

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