Electroencephalogram Signatures of Propanidid-Mediated Sedation and Unconsciousness.

Authors

Sirma Orguc, Ohyoon Kwon, Marusa Naranjo Gonzalez, Emery N Brown

Published in

Journal of neurophysiology. Jul 17, 2025. Epub Jul 17, 2025.

Abstract

Propanidid is an intravenous short-acting sedative-hypnotic anesthetic in the eugenol family that acts as a positive allosteric modulator of the gamma-aminobutyric acid type A (G A B A A) receptor. However, its neural circuit mechanisms have not been characterized. We compared the EEG signatures of patients anesthetized with propanidid to those anesthetized with propofol.
We characterized the EEG recordings of 13 propanidid- and 13 propofol-mediated general anesthesia cases using spectral and coherence analyses.
During propanidid-mediated unconsciousness, we observed a significant increase in the 0-18.5 Hz power and a decrease in the 30.5-40 Hz power compared to the baseline. Compared to the propofol cohort, the suppression in the 23-40 Hz band power was significantly less in the propanidid cohort during unconsciousness. The coherence in the 0-40 Hz range was not significantly different between the two cohorts. The propanidid cohort showed a shorter average offset time (4.8 minutes) than the propofol cohort (5.9 minutes) which was not significant.
This preliminary investigation showed that the EEG signatures of propanidid-mediated unconsciousness are similar to those of propofol suggesting a similar GABAergic mechanism of network action.
Our work provides a basis to characterize the neural mechanisms of propanidid-mediated sedation and unconsciousness.

PMID:
40673931
Bibliographic data and abstract were imported from PubMed on 17 Jul 2025.

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