N-Alkylation of Amines with 2,5-Furandimethanol to N,N'-Disubstituted 2,5-Bis(aminomethyl)furans Catalyzed by a Metal-Ligand Bifunctional Iridium Catalyst.

Authors

Beixuan Dong, Deyun Liu, Yuexin Ji, Feifei Zhou, Yuxin Zhou, Qixun Shi, Feng Li

Published in

Inorganic chemistry. Jul 17, 2025. Epub Jul 17, 2025.

Abstract

A general method for the N-alkylation of amines with 2,5-furandimethanol via hydrogen autotransfer process has been accompanied. In the presence of [Cp*Ir(2,2'-bpyO)(H₂O)] (0.5-1 mol %) and Cs₂CO₃ (0.3 equiv), a range of N,N'-disubstituted 2,5-bis(aminomethyl)furans were obtained in high yields with excellent selectivity. It was confirmed that functional groups in bpy ligand were crucially important for the activity of iridium complexes.

PMID:
40674619
Bibliographic data and abstract were imported from PubMed on 18 Jul 2025.

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