Arginine-loaded mesoporous silica nanoparticles modified 3D-printed nanocomposite denture base resin with improved mechanical and antimicrobial properties.

Authors

Zixiang Dai, Jiali An, Xiaofeng Huang

Published in

BMC oral health. Volume 25. Issue 1. Pages 1205. Jul 19, 2025. Epub Jul 19, 2025.

Abstract

Three-dimensional (3D) printed denture base resin exhibits limitations including low wear resistance, poor strength, and the lack of antimicrobial property. This study investigated the mechanical and antimicrobial properties of arginine-loaded mesoporous silica nanoparticles (Arg@MSNs) modified 3D-printed denture resin.
Arg@MSNs were synthesized, characterized, and incorporated into resin matrix at 0.5, 1.0, and 2.5 wt%, unmodified resin was served as control. Specimens were fabricated according to test specifications. Surface roughness (Ra), color alteration (ΔE), flexural strength/modulus, hardness and antimicrobial efficacy against Streptococcus mutans and Candida albicans were assessed. Data were evaluated by one-way analysis of variance, followed by the Tukey honestly significant difference post hoc test, with a significance level set at 0.05.
Results showed that Arg@MSNs exhibited sustained arginine release and nanoscale morphology. The 2.5 wt% group demonstrated the highest Ra and ΔE value, significantly higher than other groups (p < 0.05). Flexural strength and modulus significantly improved at 0.5 wt% and 1.0 wt% compared to the control (p < 0.05), but decreased at 2.5 wt%. Incorporation of Arg@MSNs at all levels increased hardness, significantly exceeding that of the control (p < 0.05). Antimicrobial performance significantly improved with higher concentrations of Arg@MSNs.
The addition of 1.0 wt% Arg@MSNs imparted synergistic enhancements in antimicrobial efficacy and mechanical properties to the 3D-printed nanocomposite, while maintaining clinically acceptable surface roughness and aesthetic performance. These findings demonstrated that Arg@MSNs modified 3D-printed nanocomposite denture base resin, by combining 3D-printed resin with nanotechnology, has promising potential for functionalized dental prostheses.

PMID:
40684164
Bibliographic data and abstract were imported from PubMed on 20 Jul 2025.

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