New cytotoxic p-hydroxybenzoic acid and sesquiterpene-derived amides from Aspergillus fumigatus J2-22-1.

Authors

Wenjie Han, Huiying Liu, Meng Ren, Nanxin Gong, Xupei Men, Yurun Wang, Taoshuai Cao, Xiaomei Song, Hongliang Tang, Xiaolong Zhao, Jun Zhang, Du-Qiang Luo

Published in

Natural product research. Pages 1-5. Jul 20, 2025. Epub Jul 20, 2025.

Abstract

Two new amides (1-2) derived from p-hydroxybenzoic acid and sesquiterpene, respectively, along with one known sesquiterpene (3), were isolated from the desert soil-derived fungus Aspergillus fumigatus J2-22-1. Structural characterisation was achieved through spectroscopic analysis, with absolute configurations confirmed via comparative ECD spectra. The anticancer potential of these compounds was evaluated against four human tumour models: MCF-7, SGC-7901, MGC-803, and HepG2. Notably, all test compounds -displayed broad-spectrum cytotoxic activities (IC₅₀ values: 20.17-94.83 μM).

PMID:
40684379
Bibliographic data and abstract were imported from PubMed on 20 Jul 2025.

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