Factors influencing recurrence after in-hospital treatment of odontogenic-related oromaxillofacial infections: a single-centre experience.

Authors

Andreas Sakkas, Majeed Rana, Mario Scheurer, Robin Kasper, Marcel Ebeling, Frank Wilde, Alisa Schramm, Jasmin Engelbrecht

Published in

BMC oral health. Volume 25. Issue 1. Pages 1273. Jul 28, 2025. Epub Jul 28, 2025.

Abstract

Evidence regarding specific factors influencing recurrence after treatment of oromaxillofacial infections is limited. This study aimed to evaluate the incidence and identify predictors of recurrence following in-hospital treatment. A secondary aim was to analyze associations between patient- and procedure-specific variables, treatment outcomes, and hospital length of stay (LOS), and to identify high-risk patients.
In this retrospective, single-center study, patients with odontogenic-related oromaxillofacial infections treated surgically or conservatively over a 4-year period were included. Demographic, clinical, radiological, and treatment data were analyzed. Multivariable analyses were performed to identify predictors of recurrence and LOS.
A total of 939 patients (mean age 44.66 ± 22.95 years) met the inclusion criteria. The recurrence rate was 5.01%, and the mean LOS was 3.55 ± 2.47 days. Increased age and BMI, mandibular infections, infections post-extraction or post-augmentation, clinical symptoms at admission (restricted mouth opening, dysphagia, non-palpable mandibular margin), elevated inflammatory markers (CRP, leukocytes, neutrophils, procalcitonin), and cervical drainage were significantly associated with higher recurrence risk and increased LOS (p < 0.05). A postoperative ICU stay increased the recurrence risk 9.13-fold.
Within the limitations of this study, the results suggest that older age, higher BMI, mandibular involvement, post-extraction or post-augmentation infections, specific clinical symptoms at admission (restricted mouth opening, dysphagia, non-palpable mandibular margin), elevated inflammatory markers, cervical drainage approaches, and stay in ICU are associated with both a higher risk of infection recurrence and increased hospital stay. Multiple bacterial strains and no continuous antibiotic therapy after discharge also indicated a higher risk of recurrence, while surgery under intubation anesthesia was linked to an increased length of stay only. These factors should be considered early in treatment planning to optimize outcomes.
Not applicable.

PMID:
40721760
Bibliographic data and abstract were imported from PubMed on 29 Jul 2025.

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