Challenges of Klebsiella pneumoniae infections post-liver transplantation: Insights and future directions.

Authors

Jian Li, Wei Wang

Published in

World journal of hepatology. Volume 17. Issue 7. Pages 107213. Jul 27, 2025.

Abstract

Klebsiella pneumoniae infections (KPIs), particularly carbapenem-resistant Klebsiella pneumoniae (CRKP), pose significant challenges in liver transplantation (LT) recipients, with high morbidity and mortality. Guo et al's study highlights risk factors, such as elevated day-one alanine aminotransferase levels and prolonged catheterization, and identifies polymyxin B and ceftazidime/avibactam as effective treatments. However, limitations like the absence of pre-transplant colonization data and host-pathogen interaction insights highlight the need for enhanced strategies. Future directions should include routine CRKP colonization surveillance, immune and genomic profiling, and the development of novel therapeutics. By integrating these approaches, we can improve the prevention, diagnosis, and treatment of KPIs in LT patients.

PMID:
40747225
Bibliographic data and abstract were imported from PubMed on 01 Aug 2025.

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