The effect of intrathecal baclofen on body mass index in children with cerebral palsy.

Authors

Maximillian Feygin, Kalman A Katlowitz, Sruthi P Thomas, Daniel J Curry, Nisha Gadgil

Published in

Journal of neurosurgery. Pediatrics. Pages 1-8. Aug 01, 2025. Epub Aug 01, 2025.

Abstract

This study aimed to investigate the effect of intrathecal baclofen (ITB) on BMI over time in a large pediatric cohort of patients with cerebral palsy (CP).
The medical records of pediatric patients diagnosed with CP who underwent ITB pump placement at Texas Children's Hospital between 2007 and 2024 were retrospectively reviewed. Pre- and postoperative BMI, demographic information, and clinical characteristics were collected. Multiple BMI velocities were calculated. A linear mixed-effects model was used to account for interpatient variability.
Among 237 patients, the average BMI was 17.90 (SD 4.00) kg/m2 preoperatively and 19.13 (SD 4.58) kg/m2 postoperatively, showing a significant difference (p = 0.001, Kruskal-Wallis test) but a small effect size (η2 = 0.02, 95% CI 0.001-0.05). The average BMI velocity was 0.55 (SD 3.5) kg/m2/yr presurgery and 0.46 (SD 3.5) kg/m2/yr postsurgery, showing no significant difference (p = 0.52, t-test). The mixed-effects model found no statistically significant effect of ITB surgery on BMI rate of change by catheter level. Specifically, cervical (p = 0.97), high thoracic (p = 0.41), midthoracic (p = 0.63), and low thoracic (p = 0.84) catheter levels were nonsignificant in effect on BMI.
Although there was an absolute increase in BMI postoperatively, the small effect size and results of the linear mixed-effects model-accounting for clinical confounders, within-patient variability, and catheter level-demonstrated that ITB surgery does not significantly affect BMI. The authors conclude that improved tone control may not substantially impact BMI, necessitating further nutritional intervention to ensure optimal BMI.

PMID:
40749238
Bibliographic data and abstract were imported from PubMed on 02 Aug 2025.

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