Evaluating the ratio of arterial partial pressure of oxygen to inspired oxygen fraction and dynamic compliance following anesthetic induction for predicting postanesthetic hypoxemia in dogs.

Authors

Minha Kim, Taehoon Sung, Changhoon Nam, Inhyung Lee, Won-Gyun Son

Published in

Veterinary anaesthesia and analgesia. Jul 10, 2025. Epub Jul 10, 2025.

Abstract

To evaluate correlation between postanesthetic induction ratio of arterial partial pressure of oxygen to inspired oxygen fraction (PaO₂:FIO₂) and dynamic compliance (C_dyn) with postanesthetic hypoxemia [PaO₂ < 80 mmHg (10.7 kPa)] in mechanically ventilated dogs, and to compare PaO₂:FIO₂ and C_dyn for predicting postanesthetic hypoxemia.
Retrospective, single-cohort, observational study.
A total of 168 dogs anesthetized with isoflurane under pressure-controlled ventilation.
Postinduction arterial blood gas (ABG) analysis was performed 5-40 minutes postintubation and following postextubation (room-air). C_dyn values were matched to the nearest postinduction ABG measurement (within 15 minutes). PaO₂:FIO₂ and C_dyn values were categorized using thresholds of 300 mmHg (40.0 kPa) and 400 mmHg (53.3 kPa), and 1.0 and 1.5 mL cmH₂O^-1 kg^-1. Linear-by-linear association was used to evaluate PaO₂:FIO₂ and C_dyn with the prevalence of postanesthetic hypoxemia. Diagnostic accuracy of these variables was assessed using receiver operating characteristic (ROC) curve analysis. Optimal cut-off values for distinguishing hypoxemia were determined using the empirical quantile bootstrap method (fixed sensitivity of 95%).
Postanesthetic hypoxemia was observed in 22/168 dogs. Lower postinduction PaO₂:FIO₂ (p = 0.033) and C_dyn (p = 0.002) values were associated with a significantly higher prevalence of postanesthetic hypoxemia. The area under the ROC curve (AUC) of PaO₂:FIO₂ {0.696 [95% confidence interval (CI): 0.599-0.807]} and C_dyn [0.716 (95% CI 0.602-0.824)] exhibited good (AUC 0.6-0.7) to satisfactory (AUC 0.7-0.8) diagnostic accuracy, with no significant difference between variables (p = 0.432). Optimal cut-off values were 332.80 mmHg (44.4 kPa) (95% CI 274.41-374.52 mmHg, 36.6-49.9 kPa) for PaO₂:FIO₂ and 1.01 (95% CI 0.86-1.13) mL cmH₂O^-1 kg^-1 for C_dyn.
Postanesthetic hypoxemia was more frequently observed in dogs with low postinduction PaO₂:FIO₂ and C_dyn. These variables had good to satisfactory diagnostic accuracy.

PMID:
40754517
Bibliographic data and abstract were imported from PubMed on 04 Aug 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.