A carrier-free therapeutic eutectogel: construction, physical properties, and anti-bacterial ability.

Authors

Jing Yuan, Zhuoni Liu, Tianxiang Yin, Shengxi Meng

Published in

RSC advances. Volume 15. Issue 34. Pages 27652-27660. Aug 01, 2025. Epub Aug 04, 2025.

Abstract

Eutectogels have emerged as promising materials with broad application potential. Herein, therapeutic deep eutectic solvents (THEDESs) based on the active pharmaceutical ingredients oxymatrine and lauric acid were developed. The physical properties, i.e., density, refractive index, surface tension, and viscosity, of the THEDESs were measured. Among these investigated THEDESs, THEDES (3 : 7) has been shown to self-aggregate into a gel in water. The rheological behavior, microscopic structure of the eutectogel, and the gelation mechanism were further explored. Furthermore, THEDES (3 : 7) can enhance the solubility and stability of curcumin effectively. The eutectogel (with and without curcumin) possessed good antioxidant and anti-P. acnes activity. To summarize, a simple method based on the self-assembly of THEDES in water was proposed to construct a therapeutic eutectogel, which could potentially be extended as a generalized strategy.

PMID:
40761903
Bibliographic data and abstract were imported from PubMed on 05 Aug 2025.

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