Authors
Latiful Kabir, Young Jun Joo, Kwang Youn Cho, Won-Chun Oh
Published in
ACS applied bio materials. Aug 05, 2025. Epub Aug 05, 2025.
Abstract
In muscle tissue, creatinine is a byproduct of creatine phosphate, which supplies energy to the muscles and is consistently filtered through the glomerulus in the kidney. In real-time and point-of-care medical diagnostics, creatinine testing can be a component of a larger panel of diagnostics used to evaluate general health and recognize any issues such as diabetes or hypertension. Consequently, we developed an enzyme-free electrochemical biosensor that enables rapid, small-volume detection of creatinine. In our biosensor, the use of active materials like MXene, SiO2, and ZnO, which have a high surface area and semiconducting properties, offers high sensitivity and is enhanced by the addition of chitosan for its superb biocompatibility and functional group (-OH, -NH2) interactions with creatinine molecules that enhance selectivity. We investigated the characterization and electrochemical properties of the SiO2-MXene-SnO2-chitosan nanocomposite using spectroscopical and electrochemical instruments. The electrochemical analyses exhibit robust sensitivity to low concentrations (0.05 μM) of creatinine within a potential range of -0.1 to 0.1 V. This enzyme-free biosensor presented a better selectivity range (0.05 μM-0.40 μM) with a correlation coefficient (R2) of 0.978 in PBS. In addition, this sensor has better reproducibility and stability for 25 days in its electrochemical analytical performance.
PMID:
40763200
Bibliographic data and abstract were imported from PubMed on 06 Aug 2025.
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