Fabrication of flexibility-rigidity alternately assembled solid-state luminescence covalent organic frameworks: application to rifampicin antibiotics detection and latent fingerprint recognition.

Authors

Qiuyi Liu, Lingling Li, Min Wang, Mingyue Wang, Yue Lan, Fan Li, Jiaqi Hu, Yuqiang Xiao, Xiurong Guo, Dandan Wang, Die Gao

Published in

Mikrochimica acta. Volume 192. Issue 9. Pages 598. Aug 16, 2025. Epub Aug 16, 2025.

Abstract

To enhance the fluorescence properties of covalent organic frameworks (COFs) for broader applications, we introduce flexibility-rigidity alternately assembled red fluorescent COFs, named COF-MA. Its uniquely wide layer spacing (7.054 Å) significantly reduces π-π stacking interactions, suppressing fluorescence self-quenching and boosting solid-state emission. With long excitation and emission wavelengths, COF-MA exhibits minimal background interference, enabling highly sensitive detection of rifampicin (RFP) and rifapentine (RPT) in complex biological samples; the detection limits for both are 6.7 ng·mL^-1. Combining experimental studies and computational simulations, we elucidated the fluorescence quenching mechanism. Furthermore, COF-MA-based fluorescent powder enabled rapid, high-contrast visualization of latent fingerprints on eight different substrates. This work not only proposes a novel structure-tuning strategy to improve COF fluorescence, but also delivers a stable probe for antibiotic detection and a versatile forensic tool, significantly expanding the practical scope of fluorescent COFs.

PMID:
40817941
Bibliographic data and abstract were imported from PubMed on 16 Aug 2025.

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