Authors
Shao-Yuan Chuang, Ching-Fang Tang, Kuan-Hung Lin, Chia-Hung Lai, Yu-Tsung Yin, Min-Kuang Tsai, Mai-Szu Wu, Mei-Yi Wu
Published in
Tuberculosis and respiratory diseases. Aug 19, 2025. Epub Aug 19, 2025.
Abstract
Solid organ transplantation (SOT) recipients are at an increased risk of posttransplant tuberculosis (TB). However, the effect of this risk on mortality remains unclear. We examined the incidence and risk factors of posttransplant TB and its effect on mortality in SOT recipients in Taiwan.
We collected data on 8205 patients who received their first transplants from 2009 to 2018 from the National Health Insurance Research Database and identified 201 new TB cases. Transplants were identified and verified by the medical procedure codes. A Cox proportional hazards model was used to identify the determinants of TB infection.
For the 7685 recipients, with 34 412 person-years (PYs), 1630 deaths (393.41/1000 PYs) were reported. Male sex was associated with a 44% increase in the risk of TB (hazard ratio [HR] = 1.44, 95% confidence interval [CI] = 1.05-1.98). In addition, age older than 65 years was associated with a 4-fold increase in the risk of TB (HR = 4.04, 95% CI = 2.04-8.00). The mortality rates in the population varied by transplantation organ type (lungs: 187.75/1000 PYs, heart: 81.11/1000 PYs, liver: 58.47/1000 PYs, pancreas: 42.36/1000 PYs, and kidneys: 23.76/1000 PYs). Recipients with posttransplant TB had a 2.53-fold increased risk of mortality (HR = 2.53, 95% confidence interval: 1.94-3.29).
Posttransplant TB is associated with an increased risk of mortality in SOT recipients. Preventing TB can mitigate this risk, which underscores the importance of monitoring and managing TB in this population.
PMID:
40827104
Bibliographic data and abstract were imported from PubMed on 19 Aug 2025.
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