dsSepbanr, a Potential RNA Biopesticide for Controlling Spodoptera exigua by Targeting the Synthesis of Sex Pheromones.

Authors

Yiqing He, Lili Wei, Chen Wang, Ruanlin Wang, Yuejun Fu

Published in

Journal of agricultural and food chemistry. Aug 19, 2025. Epub Aug 19, 2025.

Abstract

Spodoptera exigua (Hübner) is an important polyphagous agricultural pest that poses a serious threat to global agricultural production. We characterized the pheromone biosynthesis-activating neuropeptide receptor (SePBANR) in S. exigua and elucidated its critical role in sex pheromone biosynthesis and reproduction. Bioinformatic analysis and functional assays confirmed that SePBANR is a rhodopsin-like G protein-coupled receptor (GPCR). Expression of Sepbanr peaked in female adults and was essential for regulating intracellular calcium homeostasis and sex pheromone production. RNA interference (RNAi)-mediated silencing of Sepbanr significantly reduced the levels of key sex pheromones (Z9,E12-14:Ac and Z9-14:Ac), suppressed mating frequency, and decreased egg production. These findings demonstrate that Sepbanr-targeting dsRNA may serve as a potential RNAi-based biopesticide to disrupt pheromone-mediated reproduction in S. exigua.

PMID:
40828983
Bibliographic data and abstract were imported from PubMed on 20 Aug 2025.

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