Effects of lavender essential oil inhalation aromatherapy on postoperative sleep quality in patients with intracranial tumors: a randomized controlled trial.

Authors

Yang Liu, Yanmei Dong, Xin Wang, Yeqin Huang, Fan Wu, Fei Xia, Hongtong Bai, Hui Li, Lei Shi, Baoguo Wang

Published in

Frontiers in pharmacology. Volume 16. Pages 1584998. Epub Aug 04, 2025.

Abstract

To investigate the effects of lavender essential oil (LEO) on postoperative sleep quality and perioperative neurocognitive disorders (PNDs) in patients with intracranial tumors.
This study was a randomized controlled trial in which all patients were randomly assigned to either the control group, which received no intervention, or the experimental group, which received LEO. Postoperative sleep quality was assessed using a dedicated sleep monitor. The PNDs were evaluated by the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) and the Mini-Mental State Examination (MMSE), using education-adjusted cutoffs recommended by the latest Chinese Dementia Guidelines (2023).
Compared with the control group, the total sleep duration and the deep sleep duration were significantly longer in the experimental group only on the fourth postoperative day (418.48 ± 21.95 vs. 389.57 ± 49.29, P = 0.019; 95.10 ± 19.98 vs. 66.86 ± 32.69, P = 0.002). The experimental group exhibited significantly shorter sleep latency compared with the control group (13.24 ± 8.46 vs. 28.62 ± 19.86; p = 0.002). Additionally, the apnea-hypopnea index and frequency of awakenings were lower in the experimental group (14.05 ± 9.85 vs. 21.00 ± 10.78; p = 0.035; 2.67 ± 1.32 vs. 5.05 ± 2.97; p = 0.002). The duration of postoperative delirium was shorter in the experimental group compared with the control group (2.00 ± 0.82 vs. 3.80 ± 1.30; p = 0.048). On the seventh postoperative day, participants in the experimental group had lower anxiety scores than those in the control group (3.38 ± 2.27 vs. 6.14 ± 5.43; p = 0.038).
LEO inhalation aromatherapy could effectively improve postoperative sleep quality, particularly on the fourth postoperative day. It also positively impacted anxiety and reduced the duration of postoperative delirium.
https://www.chictr.org.cn/index.html, identifier ChiCTR2300073091.

PMID:
40832605
Bibliographic data and abstract were imported from PubMed on 20 Aug 2025.

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