Inhibition of DJ-1 protects from lupus onset and severity.

Authors

Mengdi Jiang, Minhui Wang, Liyan Wan, Shuangshuang Li, Chuanyin Sun, Heng Cao, Chaohui Yu, Jin Lin

Published in

Scientific reports. Volume 15. Issue 1. Pages 31217. Aug 25, 2025. Epub Aug 25, 2025.

Abstract

The DJ-1 protein, known as an oxidative stress sensor, plays an important role in immunological processes. Using DJ-1 gene knock-out mice, we identified DJ-1 as a positive regulator in systemic lupus erythematosus (SLE). DJ-1 deficiency significantly alleviated skin lesion, splenomegaly, lymphadenopathy, while reducing multiple autoantibodies and immunoglobulin levels. Moreover, DJ-1 deficiency provided protection against renal hypertrophy and decreased glomerular deposition of immunoglobulin, ultimately leading to reduced albuminuria and SLE activity. These findings demonstrate that DJ-1 expression critically influences the progression of lupus-like disease.

PMID:
40855094
Bibliographic data and abstract were imported from PubMed on 26 Aug 2025.

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