Effect of pH on the Kinetics of Cysteine-to-Cystine Conversion in Thin Films Formed by ESI Microdroplet Deposition.

Authors

Marta Managò, Chiara Salvitti, Anna Troiani, Alessia Di Noi, Andreina Ricci, Federico Pepi

Published in

Journal of the American Society for Mass Spectrometry. Aug 29, 2025. Epub Aug 29, 2025.

Abstract

The oxidation of cysteine to cystine was investigated in aqueous thin films generated by the deposition of electrospray ionization (ESI) microdroplets. The confined volume of the thin film promotes the reaction, resulting in up to 80% conversion of cysteine to cystine at a thin film temperature of 40 °C. The pH of the solution is a critical parameter, influencing both the yield and the kinetics of the reaction. Strong reaction acceleration factors in thin film with respect to the bulk were measured.

PMID:
40878648
Bibliographic data and abstract were imported from PubMed on 29 Aug 2025.

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