The value of contrast-enhanced harmonic endoscopic ultrasound in the diagnosis of periampullary mass.

Authors

Shu-Yu Chen, Qiao Qin, Xi Zhou, Ming Zhao, Xiao-Bin Sun, Jing Shan

Published in

Digestive diseases (Basel, Switzerland). Pages 1-15. Aug 30, 2025. Epub Aug 30, 2025.

Abstract

Periampullary masses encompass both benign and malignant lesions that are clinically challenging to differentiate. This study aimed to investigate the diagnostic value of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) for periampullary masses and compare its performance with computed tomography (CT) and magnetic resonance imaging (MRI).
We conducted a retrospective analysis of 54 patients with pathologically confirmed malignant periampullary masses or benign lesions validated by ≥1-year follow-up. Diagnostic efficacy of CH-EUS was evaluated against CT and MRI.
All malignant masses exhibited arterial-phase hypo-enhancement, while 78.94% of benign lesions showed iso-enhancement. Venous-phase hypo-enhancement was observed in 94.28% of malignancies and 57.89% of benign cases demonstrated iso-enhancement. CH-EUS demonstrated superior diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) compared to CT (all p<0.05). Its accuracy and sensitivity also exceeded those of MRI (p<0.05).
CH-EUS effectively differentiates benign and malignant periampullary masses, demonstrating high clinical utility.

PMID:
40884798
Bibliographic data and abstract were imported from PubMed on 31 Aug 2025.

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