GC-MS Analysis and Biological Activities of Trigonella hamosa L. and Alocasia odora (Lodd.) Spach.

Authors

Mashal Asim, Muhammad Adil, Muhammad Naseer, Asima Azam, Asma Ul Husna

Published in

Chemistry & biodiversity. Pages e01530. Aug 30, 2025. Epub Aug 30, 2025.

Abstract

The phytochemical composition and biological activities of whole plant extracts of Trigonella hamosa and Alocasia odora were investigated through gas chromatography-mass spectrometry (GC-MS) profiling and in vivo bioactivity assays. GC-MS analysis revealed a diverse range of bioactive compounds in both ethanolic and methanolic extracts. The ethanolic extract of T. hamosa contained 29 phytoconstituents, with 5-hydroxymethylfurfural (18.62%), benzoic acid (12.47%), and several fatty acids being predominant. Its methanolic extract identified 24 compounds, including 5-hydroxymethylfurfural (15.33%), methyl β-d-galactopyranoside (11.25%), and benzoic acid (9.47%). A. odora ethanolic extract showed 16 compounds, with benzyl nitrile (14.92%), benzoic acid (12.13%), and 1,2,3-benzenetriol (10.74%) as major components, whereas the methanolic extract revealed 19 compounds, including benzoic acid (13.81%), 1,2,3-benzenetriol (11.32%), and sulfur-containing compounds. Both plants' extracts exhibited significant analgesic, anti-inflammatory, and antispasmodic effects. In acetic acid-induced writhing tests, methanolic extracts of T. hamosa and A. odora reduced writhing by 71.6% and 68.4%, respectively, compared to control. In carrageenan-induced paw edema, a dose-dependent inhibition was observed, with methanolic extracts showing 63.2% (T. hamosa) and 59.7% (A. odora) edema reduction at the highest dose. Similarly, in charcoal meal tests, methanolic extracts reduced intestinal transit by 65.1% and 60.8%, respectively. Overall, the methanolic extracts of both plants demonstrated superior bioactivity across all tested models, highlighting their potential as natural therapeutic agents for managing pain, inflammation, and gastrointestinal disturbances.

PMID:
40884825
Bibliographic data and abstract were imported from PubMed on 31 Aug 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.