Efficacy and safety of low-temperature plasma radiofrequency ablation combined with ozone injection versus triple therapy including collagenase for cervical disc herniation: a randomized controlled trial.

Authors

Ying Yang, Zhenguo Gao, Yulin Zhang, Qifan Fang, Jiang Liu, Yongming Zhao, Zeyu Wu

Published in

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. Sep 04, 2025. Epub Sep 04, 2025.

Abstract

To compare the efficacy and safety of low-temperature plasma radiofrequency ablation combined with ozone injection versus the same dual therapy with additional collagenase for cervical disc herniation (CDH).
A prospective RCT enrolled 90 eligible CDH patients (30-80 years, single-level protrusion ≤ 1/3 spinal canal) at a tertiary hospital, randomizing them to a study group (n = 45, triple therapy) or control group (n = 45, low-temperature plasma radiofrequency ablation + ozone). Visual Analogue Scale (VAS) and Japanese Orthopaedic Association (JOA) scores were compared preoperatively and at 1 week, 1, 3, and 6 months postoperatively, with efficacy assessed via Modified MacNab Criteria.
At 6 months, the study group showed significantly better VAS and JOA scores (P < 0.05) and a 6-month excellent rate of 93.33% vs. 75.56% in controls (P < 0.05). Both groups improved postoperatively, with no early differences. No severe adverse events occurred.
The addition of collagenase to ablation and ozone therapy significantly enhances long-term pain relief and functional recovery in CDH patients without increasing safety risks.

PMID:
40903674
Bibliographic data and abstract were imported from PubMed on 04 Sep 2025.

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