Creating skeletal complexity through an interrupted Corey-Chaykovsky reaction of activated alkynes.

Authors

Nisha Yadav, S S V Ramasastry

Published in

Chemical communications (Cambridge, England). Sep 04, 2025. Epub Sep 04, 2025.

Abstract

We present the first interrupted Corey-Chaykovsky reaction of α,β-ynones by intercepting the zwitterionic intermediates that prevail during the addition of the Corey-Chaykovsky reagent to activated alkynes. This cascade transformation uncovers a novel mechanistic feature and leverages it to construct complex polycyclic molecular architectures featuring three new carbon-carbon bonds, four new carbo- and heterocycles and four contiguous stereocenters, two of which are quaternary carbons, all in a single-pot operation. Additionally, we demonstrate the synthetic utility of these otherwise unprecedented molecules.

PMID:
40905124
Bibliographic data and abstract were imported from PubMed on 04 Sep 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.