Authors
Edward S Lu, Yifan Lu, Ying Cui, Rebecca Zeng, Ying Zhu, Xinyi Ding, Raviv Katz, Rongrong Le, Itika Garg, Jay C Wang, Demetrios G Vavvas, Deeba Husain, Joan W Miller, David M Wu, John B Miller
Published in
Retina (Philadelphia, Pa.). Sep 03, 2025. Epub Sep 03, 2025.
Abstract
To investigate associations among expanded field swept-source optical coherence tomography angiography (SS-OCTA) biomarkers and the development of tractional retinal detachment (TRD) in patients with proliferative diabetic retinopathy (PDR).
Patients with PDR without TRD at baseline were imaged with SS-OCTA. Quantitative and qualitative OCTA metrics were independently evaluated by two trained graders. A logistic regression model was utilized to identify OCTA biomarkers associated with TRD development.
Forty-nine PDR eyes from 38 participants were included. Seven of 49 eyes (14%) developed TRD over a median of 576 (range 35-805) days. Biomarkers associated with TRD were: large retinal non-perfusion area (NPA) (odds ratio [OR], 7.84; 95% confidence interval [CI], 2.61 - 16.3; p = 0.04), presence of neovascularization (NV) with total area > 4 disc diameters, (OR, 2.30; 95% [CI], 1.09 - 4.51; p = 0.04), and presence of tabletop NV (OR, 2.64; 95% [CI], 1.42 - 4.86; p = 0.02), defined as NV displaced anteriorly by vitreous traction but tethered to the retina by vascular membranes.
Presence of large retinal NPA, extensive NV, and NV with features of anterior displacement by vitreous traction were associated with increased risk of TRD occurrence. SS-OCTA may be useful for predicting diabetic TRD development.
PMID:
40924901
Bibliographic data and abstract were imported from PubMed on 10 Sep 2025.
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