Authors
Linru Bai, Benqi Chen, Yan Xu, Mingjia Liu, Yunhui Yang, Jianmei Yang, Rong Hu
Published in
Mikrochimica acta. Volume 192. Issue 10. Pages 661. Sep 12, 2025. Epub Sep 12, 2025.
Abstract
Au NPs@FGO@Fe MOG were sythesized for its inaugural application in biosensor development and engineered as a novel, highly efficient electrochemical aptasensor for the precise detection of interleukin-6 (IL-6). The aptasensor architecture integrates Au NPs@FGO@Fe MOG as the electrode interface and an anemone-like PtNi nanoclusters@MIL-anchored three-dimensional DNA (PD) network as the signal transduction matrix. The as-prepared Au NPs@FGO@Fe MOG exhibited an exceptionally high specific surface area, excellent electrical conductivity, and robust structural stability, collectively contributing to a pronounced enhancement in the performance of an electrochemical biosensor. The hierarchically PD network provided abundant binding sites for the redox-active probe thionine (Thi), thereby amplifying the electrochemical signal with remarkable efficiency. Under optimized conditions, the aptasensor achieved an impressive detection limit of 0.89 pg/mL. Moreover, the platform demonstrated reliable performance in detecting IL-6 in unspiked human serum samples, with results exhibiting high concordance with those obtained from commercial enzyme-linked immunosorbent assay (ELISA) kits. These findings demonstrate the considerable potential of this platform for rapid, sensitive, and accurate cytokine quantification, offering valuable prospects for clinical diagnostic applications.
PMID:
40938438
Bibliographic data and abstract were imported from PubMed on 12 Sep 2025.
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