Authors
Robert Frithiof, Micael Taavo, Arash Emami, Stephanie Franzén
Published in
American journal of physiology. Renal physiology. Sep 12, 2025. Epub Sep 12, 2025.
Abstract
Hemorrhage and hypotension leading to renal hypoperfusion are common causes of acute kidney injury (AKI). Anesthetic agents may affect renal hemodynamics, potentially altering renal outcomes during hypovolemia. This study evaluated the effects of two commonly used anesthetics, propofol and sevoflurane, on renal blood flow (RBF) and oxygenation during hemorrhage. Fourteen pigs (30 ± 2 kg) were anesthetized with either propofol or sevoflurane, with fentanyl as an opioid supplement in both groups. Following baseline measurements, hemorrhage was induced to maintain a mean arterial pressure (MAP) below 50 mmHg for 30 minutes, after which resuscitation was performed using a 1:1 replacement of whole blood and Ringer's acetate. Acute renal function recovery was evaluated one hour post-resuscitation. At baseline, sevoflurane anesthetized animals had lower RBF and renal oxygen delivery, and higher renal vascular resistance compared with the propofol group. During hemorrhage the change in these variables were comparable. After resuscitation, cardiovascular and RBF recovery was similar between the groups. However, oxygen delivery remained significantly lower in the sevoflurane group compared with the propofol group. Additionally, renal vascular resistance was significantly higher during sevoflurane anesthesia compared with propofol after recovery. In conclusion, compared with propofol anesthesia, sevoflurane anesthesia reduced RBF and renal oxygen delivery already at baseline. The difference in oxygen delivery persisted after hemorrhage even though RBF was comparable between groups.
PMID:
40939017
Bibliographic data and abstract were imported from PubMed on 13 Sep 2025.
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