Authors
Billy Moore, Shannon McMahon, Michael Izumiyama, Taewoo Ryu, Timothy Ravasi
Published in
iScience. Volume 28. Issue 9. Pages 113395. Sep 19, 2025. Epub Aug 19, 2025.
Abstract
Ocean warming and marine heatwaves are predicted to have adverse impacts on marine organisms. Yet, knowledge of the molecular mechanisms that underpin successful or failed acclimation to increasing temperatures remains incomplete. We conducted an aquaria-based study of early-life stage clownfish comprising of six thermal regimes, measuring the metabolic, and multi-tissue transcriptional response of Amphiprion ocellaris using seven tissues. Sampling at 31°C increased metabolic rates in fish reared at 28°C; however, these effects were reduced with increasing developmental rearing at 31°C. Transcriptomic analysis revealed multi-tissue reprogramming of metabolic processes at +3°C, particularly in the liver-pancreas axis. Importantly, chronic larval-juvenile exposure to +3°C induced the acclimation of metabolic rates and caused the upregulation of oxidative phosphorylation (liver) and the downregulation of insulin secretion (pancreas). These results indicate that temperature increase will drive tissue-wide metabolic reprogramming in fish, with changes in key energetic pathways underpinning fish's ability to acclimate to warming.
PMID:
40970204
Bibliographic data and abstract were imported from PubMed on 19 Sep 2025.
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