Catalyst-Controlled Switchable Mono-/Di-C-H Arylation of Aromatic Amides with Arylsilanes.

Authors

Menglong Lu, Deyu Wu, Tingting Hou, Xin Yang, Mengmeng Li, Wenwu Liu, Heng Xu, Yi Dong

Published in

Organic letters. Sep 20, 2025. Epub Sep 20, 2025.

Abstract

The selective mono/di-C-H arylation of aromatic amides has been developed, enabling efficient coupling with arylsilanes under mild conditions with good functional group tolerance. The regioselectivity (mono- vs diarylation) is catalyst-dependent, with [Cp*RhCl₂]₂ selectively promoting monoarylation, whereas [Cp*IrCl₂]₂ demonstrates a distinct preference for diarylation. This approach establishes a straightforward and efficient strategy for the late-stage arylation of pharmaceutical compounds.

PMID:
40974113
Bibliographic data and abstract were imported from PubMed on 20 Sep 2025.

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