Two novel 5,5-spiroketal sesquiterpenoid isomers from the roots of Angelica biserrata (R. H. Shan &Yuan) C. Q. Yuan & R. H. Shan.

Authors

Fuyong Ni, Rongrong Li, Zixian Xie, Ying Li, Ningning Xu, Xuanyu Mu, Ming Yan, Chenfeng Zhang, Zhenzhong Wang, Xue Xie, Wei Xiao

Published in

Natural product research. Pages 1-7. Sep 21, 2025. Epub Sep 21, 2025.

Abstract

Two novel 5,5-spiroketal sesquiterpenoid isomers, duhuosesquid A (1) and duhuosesquid B (2) were isolated from the roots of Angelica biserrata (R. H. Shan & Yuan) C. Q. Yuan & R. H. Shan. Their structures were determined by extensive spectroscopic analyses, and the absolute configurations of 1 and 2 were assigned via NMR calculations and ECD calculations. Additionally, their anti-inflammatory activities were evaluated through in vitro assays, with IC₅₀ values of 15.9 ± 1.2 μM and 14.2 ± 0.5 μM, respectively.

PMID:
40975862
Bibliographic data and abstract were imported from PubMed on 22 Sep 2025.

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