A sensitive 2D Cu-TCPP-based respiratory ammonia sensor for non-invasive and more accessible detection of Helicobacter pylori infection.

Authors

Yiran Wang, Mingwan Su, Lei Li, Miao Li, Jincai He, Zhenxia Zhao, Guangxi Li, Zhongxing Zhao, Min Li

Published in

Chemical communications (Cambridge, England). Sep 23, 2025. Epub Sep 23, 2025.

Abstract

This study created a sensitive Raman ammonia sensor using 2D Cu-TCPP nanosheets for noninvasive H. pylori detection. Leveraging multiple ammonia-binding sites and Au nanoparticle signal enhancement, it achieved a 1 ppm detection limit. Testing patients' breath, it identified H. pylori via ammonia levels, showing clear I₉₉₇/I₁₀₃₀ ratio shifts post-urea intake, offering a promising noninvasive diagnostic tool.

PMID:
40985118
Bibliographic data and abstract were imported from PubMed on 23 Sep 2025.

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